💉 What exactly is the Rejuran PN? Why do people with delicate skin in South Korea use it?
If you search for “#Rejuran PN” or “#Rejuran” on Instagram, you will see countless selfies of South Korean women with glowing skin. This PDRN product, developed by the South Korean company PharmaResearch, has been widely used in Dermatology clinics in South Korea for several years, but many people in Taiwan are still not familiar with it. When I first heard about it, I was completely confused – what exactly is a “black box,” and how is it different from hyaluronic acid injections?
To conclude: Rejuran PN is a manually administered PDRN repair injection, not delivered by a hyaluronic acid injection device. Doctors inject it into the dermis layer one needle at a time. Its key ingredient is PN (Polydeoxyribonucleotide), extracted from salmon testes, which has a 98% similarity in base pair sequence to human DNA. As a result, the skin absorbs it very effectively, and the risk of allergic reactions is extremely low.
The main difference between it and ordinary hyaluronic acid injections is that while hyaluronic acid injections primarily serve to hydrate the skin (by using Filler), Rejuran PN works through repair and regeneration – it restores damaged skin barriers, promotes the production of new Collagen, and improves skin quality from within. Many people describe the effect after treatment as their skin “glowing from within,” rather than simply experiencing a superficially hydrated look.
🔬 Rejuran PN Black Box, White Box, or Red Box: What are the differences?
Many people have difficulty distinguishing the three colors of Rejuran, so here is a comparison table for your reference👇
| Comparative projects | ⚫ Black Box Healer | ⚪ White-box HB | 🔴 Red Box |
|---|---|---|---|
| Core ingredients | PN (high molecular weight) | PN (improved version) | PDRN (low molecular weight) |
| Main benefits | Full-face restoration and anti-aging treatment | Specifically designed for the area around the eyes | Basic skincare / Acne scar repair |
| Injection method | Manual intervention (performed by a doctor) | Manual typing | It can be typed or handwritten. |
| capacity | 2 centum cores per vial | 1 centum core per vial | 2 centum cores per vial |
| Reference price | ₩250,000 to ₩380,000 | ₩200,000 to ₩300,000 | ₩150,000 to 250,000 |
| Effect maintenance | 6 to 12 months | 3 to 6 months | 3 to 6 months |
💡 How to choose?: For overall skin improvement, choose the Black Box set; for fine lines around the eyes/Dark circle treatment, choose the White Box set; if your budget is limited or you need to repair acne scars, choose the Red Box set. Doctors may also recommend combining the Black Box and White Box sets for better results.
📋 My complete experience using the Rejuran PN at ABIJOU in Gangnam
This time, I had the treatment at the Gangnam ABIJOU Dermatology clinic. The reason I chose this clinic is that the director has extensive experience in performing such procedures manually, and many Taiwanese customers have left positive reviews on Naver.
💬 To make an appointment, simply add me on WeChat: s-sourire.
One week before the procedure, I infor
med them of the treatments I wanted, and they quickly arranged a schedule for me and provided Chinese translations for all the relevant information. I also sent them a photo of my natural face, and after seeing it, the director suggested that 1 cc of black box filler for the whole face would be sufficient – no need to increase the amount. Such a practice, where there is no unnecessary push for additional services, really makes people feel at ease.
📱 If you don’t have access to WeChat, you can also use BeautsGO. On the platform, you can directl
y book appointments at clinics that offer Rejuran PN; the prices are transparent, and customer service is available in traditional Chinese throughout the process.
🩺 In-person consulta
tion
The director examined my face using a dermatoscope and said that my overall skin condition was good, but there was slight damage to the skin barrier (caused by seasonal sensitivity). The Black Box treatment would be perfect for repairing this issue. She also suggested that I use a basic hyaluronic acid serum in combination for even better results. I agreed, and the final treatment plan was 2 cc of Black Box + 3 cc of hyaluronic acid serum.
⚡ Treatment Process
First,
apply an anesthetic ointment for 30 minutes. The injections were done manually by the hospital director using very fine needles (around 32G) at intervals of approximately 1 cm on the face. The cheeks, forehead, and chin were all injected, while the area around the nose was avoided. Each injection caused a slight stinging sensation and mild swelling, but it was much less painful than expected—the discomfort was roughly on the scale of 4 to 5 on a pain scale. The entire manual injection process took about 15 minutes. Afterwards, hyaluronic acid injections were administered using a machine, which took approximately 10 minutes.
🧴 After the proced
ure
There were some small bumps on my face (a normal reaction after the treatment). The nurse applied ice compresses and a calming facial mask for 20 minutes. By the time I left, the bumps had mostly subsided, but my face was slightly red, as if I had gotten sunburned. The nurse instructed me not to get my face wet, not to wear makeup, and to avoid sweating for 24 hours. The next day, I could wash my face and apply makeup as usual.
⏰ How often should Rejuran PN be used? What is the most effective way to schedule the treatment?
This is the question that people ask most frequently. Unlike hyaluronic acid injections, which can be administered monthly, Rejuran PN has its own schedule:
📌 First treatment course (intensive phase): 3 sessions in a row, with an interval of 2–4 weeks between each session. This stage is designed to build the skin’s foundational repair capabilities, and the effects will become increasingly noticeable with each treatment. Many people may not notice much change after the first session, but by the third session, they will realize that “their skin is really different.”
📌 Maintenance period: After the first treatment, one booster dose every 6–12 months is sufficient to maintain the effects. The specific interval depends on individual lifestyle habits; those who often stay up late, smoke, or expose themselves to excessive sunlight may need to receive booster doses more frequently.
⚠️ Note: There should be at least a 2-week interval between two treatments with the black box device, to allow PDRN sufficient time to exert its reparative effects on the skin. Performing the treatments too frequently will not result in better outcomes; instead, it will only lead to waste of money.
🚫 Contraindications and risks of Rejuran PN
Although the Rejuran PN is very safe (with 98% similarity to human DNA), it is not recommended for use in the following situations:
❌ Pregnancy and lactation: Although there are no clear studies indicating any harm, it is not recommended for safety reasons.
❌ Active acne/severe inflammation: Getting injections may exacerbate the infection; it is recommended to treat the acne before proceeding with the treatment.
❌ Autoimmune diseases: Since PDRN triggers an immune repair response, patients with autoimmune diseases may experience adverse reactions.
❌ Allergy to fish protein: PDRN is extracted from salmon, so it may not be suitable for individuals who are allergic to fish protein.
⚠️ Common side effects: Swelling at the injection site (subsides within 1–2 days), slight redness (disappears within a few hours), and mild bruising (varies from person to person; applying ice can help reduce discomfort). Severe side effects are extremely rare.
💡 Additional note: Some people may experience particularly dry skin the day after receiving the black box treatment, but this is normal – PDRN consumes some moisture while triggering the repair process in the dermis. At this time, it’s better to use a highly occlusive repair cream to retain moisture rather than applying excessive face masks. Personally, I find that applying Cell Fusion C Repair Cream followed by Illiyoon Neuroamide Moisturizing Cream in two layers yields excellent results. South Korean Dermatology doctors also recommend drinking 2 liters of water daily for one week after the treatment to help replenish moisture from within the body.
❓ FAQ on Common Issues Related to Rejuran PN
Q: Which is better, Rejuran PN or Juvelook?
A: They are two different products. Rejuran PN
is a restorative treatment that promotes Collagen regeneration, while Juvelook is a filler made from PCL Collagen. If you want to improve the overall quality of your skin, choose Rejuran PN; if you are looking to address Tear trough correction or other areas of indentation, Juvelook is the better option. Many people use them together – Rejuran PN first to restore the skin’s structure, followed by Juvelook for targeted filling, resulting in a synergistic effect where the results are better than using either product alone.
Q: How soon can I see the results after the treatment
?
A: Immediately after the treatment, the skin will feel “hydrated” (due to the absorption of moisture), but the actual repair effects of PN take 2–4 weeks to become apparent. The best results are usually achieved after three treatments in the first session. Many Dermatology clinics in South Korea recommend a follow-up appointment one month after the treatment to assess the recovery progress; the doctor will then determine whether any adjustments are needed for the next treatment plan.
Q: Can I buy the Rejuran PN kit and use it on myself?
A: Abs
olutely not! The Rejuran PN kit must be used by a licensed doctor. The depth, angle, and distribution of the injections require professional expertise. There are many counterfeit products on the black market, and damaging your face in this way would be absolutely not worth it.
Q: What are the differences between it and the British version of Enhance?
A
: In fact, both are products developed by PharmaResearch, but they come in different packaging and have different names in different regions. In South Korea, it is called Rejuran, while in Taiwan and Southeast Asia, it is called Enhance. The ingredients and effects are the same; the only difference lies in the marketing names.
⚠️ Disclaimer: This article is merely a sharing of personal experiences and does not constitute medical advice. The results of cosmetic procedures can vary from person to person; it is recommended to seek professional evaluation through a face-to-face consultation with a doctor. The price information provided is for reference only; the actual charges will be determined by the clinic.
